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LSD, or lysergic acid diethylamide, is a hallucinogenic drug that was first synthesized a Swiss scientist in the 1930s. During the Cold War, the CIA conducted clandestine experiments with LSD (and other drugs) for mind control, information gathering and other purposes. Over time, the drug became a symbol of the 1960s counterculture, eventually joining other hallucinogenic and recreational drugs at rave parties.

Albert Hofmann and Bicycle Day

Albert Hofmann, a researcher with the Swiss chemical company Sandoz, first developed lysergic acid diethylamide or LSD in 1938. He was working with a chemical found in ergot, a fungus that grows naturally on rye and other grains.

Hofmann didn’t discover the drug’s hallucinogenic effects until 1943 when he accidentally ingested a small amount and perceived “extraordinary shapes with intense, kaleidoscopic play of colors.”

Three days later, on April 19, 1943, he took a larger dose of the drug. As Hofmann rode home from work on his bicycle—World War II restrictions made automobile travel off-limits—he experienced the world’s first intentional acid trip.

Years later, April 19 came to be celebrated by some recreational LSD users as Bicycle Day.

LSD Effects

LSD is just one mind-altering substance in a class of drugs called hallucinogens, which cause people to have hallucinations—things that someone sees, hears or feels that appear to be real but are in fact created by the mind.

LSD users call these hallucinogenic experiences “trips,” and LSD is a particularly strong hallucinogen. Because its effects are unpredictable, there’s no way to know when taking the drug whether a user will have a good trip or not.

Depending on how much a person takes or how their brain responds, a trip can be pleasurable and enlightening, or, during a “bad trip,” a user may have terrifying thoughts or feel out of control.

Long after they’ve taken the drug, some users experience flashbacks, when parts of the trip return without using the drug again. Researchers think LSD flashbacks may happen during times of increased stress.

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